Mildred Rebstock: Profile of the Medicinal Chemist Who Synthesized Chloramphenicol

Antimicrob Agents Chemother. 2019 May 24;63(6):e00648-19. doi: 10.1128/AAC.00648-19. Print 2019 Jun.

Abstract

This year marks the 70th anniversary since Parke-Davis and Company announced the synthesis of chloramphenicol, the first naturally occurring antibiotic to be chemically generated in vitro for large-scale production. The effort was led by the chemist Mildred Rebstock, Ph.D., (1919 to 2011), who would turn 100 years old this year. Her accomplishment, at a time when very few chemists in the United States were women, was celebrated internationally. This commentary reviews her important contribution.

Keywords: antibiotics; chloramphenicol; history.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Chloramphenicol / chemical synthesis*
  • Chloramphenicol / chemistry*
  • Female
  • Humans

Substances

  • Anti-Bacterial Agents
  • Chloramphenicol